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CASorganic LLC - Your partner in biochemical's industry

 

CasOrganic's US Corporation offers versitile biochemicals and fine chemicals, peptide reagents which include coupling reagents, N-protecting reagents and miscellaneous compounds that might be used in amide bond formation. In recent years, peptide coupling reactions have been significantly advanced in accord with the development of new peptide coupling reagents in organic synthesis. Research and development of new peptide coupling reagents has been steadily accelerated in the past few years. Moreover, tremendously expanded applications have been possible to new and broad synthetic challenges. Among many, coupling reagents responsible for the formation of azide, mixed anhydride, and acid halide intermediates have gained substantial popularity in peptide coupling reactions. DCC as a peptide-coupling reagent has particularly attracted organic chemists in their synthesis of complex molecules. Moreover, the development of onium-type coupling reagents has made the incorporation of non-coded or sterically hindered amino acids including N-methylated and a,a-dialkylated amino acids smoothly into the corresponding peptides possible.

 

Featured Products

 

Phosphonium reagents

Uronium reagents

Immonium reagents

Carbodiimide reagents

Imidazolium reagents

Organophosphorous reagents

Acid halogenating reagents

Chloroformate, pyridinium and other coupling reagents

Racemisation suppressants

 

Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound [1]. Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields [2,3].
Product Description
Product Name
HBTU
Structure
IUPAC Name, Synonims
O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUORO-PHOSPHATE
O-(7-AZABENZOTRIAZOLE-1-YL)-N, N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE
O-(7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE
O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE
N,N,N',N'-TETRAMETHYL-O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPATE
N,N,N',N'-TETRAMETHYL-O-(7-AZABENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPHATE
N-[(DIMETHYLAMINO)-1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINO-1-YLMETHYLENE]-N-METHYLMETHANAMINIUM HEXAFLUOROPHOSPHATE N-OXIDE
o-(7-azabenzotriazol-1-yl)-n,n,n’,n’-te-tramethyluroniumpf6
HATU
2-(7-AZA-1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE
2-(1H-7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYL URONIUM HEXAFLUOROPHOSPHATE METHANAMINIUM
1-[BIS(DIMETHYLAMINO)METHYLENE]-1 H-1,2,3-TRIAZOLO(4,5-B) PYRIDINIUM 3-OXIDE HEXAFLUOROPHOSPHATE
O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TE&
HATU 2-(7-AZOBENZOTRIAZOLYL-1-OXY)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE 99%
2-(7-AZA-1H-BENZOTRIAZOLE-1-YL)-1,1,3,3- TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE (HATU)
O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethylur
O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE (HATU)
O-(7-AZABENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE (HATU)
HATU O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE
O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLUROINIUM HEXAFLUOROPHOSPHATE
azabenzotriazolyl tetramethyluronium hexafluorophosphate
HATU, N,N,Nμ,Nμ-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate
HATU impregnated tablets, N,N,Nμ,Nμ-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate impregnated tablets, ChemDose(R) O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate tablets, O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate impregnated tablets
O-(7-Azabenzotriazol-1-yl)-N,N,Nμ,Nμ-tetramethyluronium hexafluorophosphate, ChemDose(R) tabletsO-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
CAS No
94790-37-1
Molecular Formula
C11H16F6N5OP
Molecular Weight
379.3
Refractive index
  
Density
Appearance
White to off-white crystalline powder
Melting Point
202 - 212°C
Purity
>98%
Loss on dryging
<0.5%
Heavy metals
<20 ppm
Packing
1kg; 25kg; 50kg
References
1. I. Abdelmoty Lett. Pept. Sci. 1, 57, (1994)
2. L.A. Carpino etal. Angew. Chem. Int. Ed. 41, 441, (2001)
3. R. Knorr Tetrahedron Lett. 30, 1927, (1989)
V. Dourtoglou Synthesis, 572, (1984)
L.A. Carpino et al. Angew. Chem. Int. Ed. 41, 441, (2001)