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CASorganic LLC - Your partner in biochemical's industry


 

CasOrganic's US Corporation offers versitile biochemicals and fine chemicals, peptide reagents which include coupling reagents, N-protecting reagents and miscellaneous compounds that might be used in amide bond formation. In recent years, peptide coupling reactions have been significantly advanced in accord with the development of new peptide coupling reagents in organic synthesis. Research and development of new peptide coupling reagents has been steadily accelerated in the past few years. Moreover, tremendously expanded applications have been possible to new and broad synthetic challenges. Among many, coupling reagents responsible for the formation of azide, mixed anhydride, and acid halide intermediates have gained substantial popularity in peptide coupling reactions. DCC as a peptide-coupling reagent has particularly attracted organic chemists in their synthesis of complex molecules. Moreover, the development of onium-type coupling reagents has made the incorporation of non-coded or sterically hindered amino acids including N-methylated and a,a-dialkylated amino acids smoothly into the corresponding peptides possible.

 

Featured Products

 

Phosphonium reagents

Uronium reagents

Immonium reagents

Carbodiimide reagents

Imidazolium reagents

Organophosphorous reagents

Acid halogenating reagents

Chloroformate, pyridinium and other coupling reagents

Racemisation suppressants

 

BOP-reagent is a reagent commonly used in the synthesis of peptides. Its use is discouraged because coupling using BOP liberates HMPA, which is carcinogenic. Although for small scale use in an organic laboratory this is not a great disadvantage as it is in large scale industrial usage:
Product Description
Product Name
BOP
Structure
IUPAC Name, Synonims
benzotriazol-1-yl-oxytris(dimethylamino)phosphoniumhexa-fluorophosphate(bop)
BENZOTRIAZOLYL-N-OXYTRIS-(DIMETHYLAMINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE)
BENZOTRIAZOLE-1-YL-OXY-TRIS-DIMETHYLAMINOPHOPHONIUM
BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOSPHONIUM HEXAFLUOROPHOSPHATE
BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOSPHONIUM
BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOPHONIUM HEXAFLUOROPHOSPHATE
BENZOTRIAZOL-1-YLOXYTRIS(DIMETHYLAMINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE
BOP REAGENT
BOP
CASTROS REAGENT
CASTRO'S REAGENT
HEXAFLUOROPHOSPHATE BOP
1H-BENZOTRIAZOL-1-YLOXYTRIS(DIMETHYLAMINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE
BENZOTRIAZOL-1-YLOXYTRIS(DIMETHYLAMINO)- PHOSPHONIUM HEXAFLUOROPHOSPHATE, 97
BENZOTRIAZOLYL-N-OXY-TRIS(DIMETHYL-*AMINO)PHOSPHONIU
BOP REAGENT:BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOSPHONIUM HEXAFLUOROPHOSPHATE
BOP [BENZOTRIAZOLE-1-YL-OXY-TRIS-(DIMETHYLAMINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE]
Benzotriazol-1-yloxytris(dimethylamino)phosphonium
Benzotriazol-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorphosphate(BOP)
Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate, 98+%
BOP BENZOTRIAZOL-1-YLOXY)TRIS(DIMETHYLAMINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE
BOP reagent, 99% min.
BENZOTRIAZOL-1-YL-OXY-TRIS-(DIMETHYLAMINO)-PHOSPHONIUM HEXAFLUORPHOSPHATE
Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate
BENZOTRIAZOL-1-YL-OXY-TRIS(DIMETHYLAMINO)PHOSPHONIUM HEXAFLUOROPHOSPHATE (BOP REAGENT)
BOP, BENZOTRIAZO-1-YLOXY-TRIS[DIMETHYLAMINO]PHOSPHONIUM HEXAFLUOROPHOSPHATE
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate [Coupling Reagent for Peptide]
benzotriazol-1-yloxytris(dimethylamino)phosphonium PF6
BOP Reagent, BOP, Castros reagent
Phosphorus(1+), (1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)-, (T-4)-, hexafluorophosphate(1-)
CAS No
56602-33-6
Molecular Formula
C12H22F6N6OP2
Molecular Weight
442.5
Appearance
White crystalline powder
Melting Point
135-140 °C
Purity
>99%
Loss on dryging
<0.5%
Heavy metals
<25ppm
Packing
1kg; 25kg; 50kg
References
2006Synthesis, 2677, (2006)
Fieser 6,34 / Fieser 7,14